Ngesizathu esivakalayo,gelatinsesinye sezona zinto zisetyenziswa ngokuqhelekileyo kwimichiza nezonyango.Inyamezelwa ngokubanzi kwihlabathi jikelele, inenzuzo egqithileyo kunye neempawu ezicacileyo, inyibilika kubushushu bomzimba kwaye iyancibilika.IGelatin yinto eguquguqukayo kakhulu enezibonelelo ezahlukeneyo kwiimveliso zamayeza ezinjengeepilisi kunye neetafile, phakathi kwabanye.
Omabini amaqokobhe ee-capsules aqinileyo kunye athambileyo aqhele ukwenziwa ngegelatin, ekhusela ngokufanelekileyo iziqulatho kwizinto ezingcoliswa ngumoya, uphuhliso lwemicrobial, ukukhanya, ioksijini, ungcoliseko, incasa kunye nevumba.
Iicapsules ezinzima
I-75 yepesenti ye-gelatin capsule market yenziwe ngee-capsules ezinzima.1 Zikwabizwa ngokuba zii-capsules ezinamaqhekeza amabini kwaye zenziwe ngamaqokobhe amabini angama-cylindrical atywinwe ngokwe-hermetically kunye nekepusi elingana kakuhle emzimbeni.Kubantu, zingenziwa ngobukhulu ukusuka kwi-00 ukuya kwi-5, kwaye ziyakwazi ukuguquguquka okanye zibe nemibala.Kwakhona kunokwenzeka ukuprinta.
Iipowders, iigranules, iipellets, kunye neepilisi ezincinci zihlala zisetyenziswa njengezizalisi kwiicapsules ezinzima.Ukusebenzisa ubuchule obudalelwe ukutywina kunye nokupakisha ii-capsules ngelixa uphakamisa imimiselo yokhuseleko lwamachiza, zinokuzaliswa ngolwelo kunye neepasti.
Iicapsules ezithambileyo
Iicapsules ezithambileyo, kwelinye icala, inzuzoigelatin yamayezaUmthamo wokunyibilika emanzini ashushu kwaye uqina xa kubanda.Baneqhekeza elinye, elitywiniweyo elithambileyo elitywiniweyo.Banokuvelisa amaqokobhe aneendlela ezahlukeneyo kunye nemibala ngokusebenzisa i-liquid okanye i-semi-solid filler.
Nangona zibala kuphela malunga ne-25% yemarike ye-gelatin capsule, ii-capsules ezithambileyo zineenzuzo ezahlukeneyo kwiifom ezininzi zedosi yomlomo eqhelekileyo.Ziquka ukunyuka kokugwinya, ukukhuselwa kwe-APIs, kunye nokuchithwa ngokukhawuleza kwi-gastrointestinal tract gastric fluids.Ngaphezu koko, xa kuthelekiswa neefom zedosi eqhelekileyo, ukufunxwa kwezinto ezinganyibiliki kakuhle ezibandakanyiweyo kwiicapsules ezithambileyo kunokonyuka.
Amacwecwe
I-Gelatin ingasetyenziselwa ukugquma okanye ukubopha iipilisi, ukubonelela ngenketho efikelelekayo kwiipilisi.Akukho thuba lokudibanisa kunye neetafile, ezikwabonelela ngokhetho lokukhangela ulwahlulo lwethamo.
Amacwecwe, ngakolunye uhlangothi, anokusetyenziswa kuphela kunye ne-excipients eqinile kunye ne-APIs, kwaye ukuchithwa kuncinci, ukuqulunqwa kunomngeni, kwaye kukho ukukhuselwa okuncinci kumacandelo asebenzayo ukusuka emoyeni nasekukhanyeni.Ngaphezu koko, ukuginya kunzima ngakumbi.
Ngexesha legranulation, igelatin inokusebenza njengesibophelelo sokubamba umgubo onjengestatshi, izinto eziphuma kwiselulosi, kunye nentlaka yeacacia kunye.Iingubo zeGelatin nazo zinokunceda ekujonganeni nezinye iintsilelo zamacwecwe.Ziquka ukuphucula ukugwinya, ukunciphisa ukunambitheka kunye nephunga, kunye nokuncedisa ekukhuseleni i-APIs kwi-oksijini kunye nokukhanya, phakathi kwezinye izinto.
Izixhobo zonyango
IGelatin ineenzuzo ezininzi ezenza ukuba ilungele uluhlu lwezicelo zokhathalelo lwempilo.Iphantse yanyamezelwa jikelele, ine-cytocompatibility egqwesileyo kunye ne-immunogenicity encinci.Ikwahlanjululwe kakhulu ngaphandle komngcipheko wongcoliseko kwaye, ukongeza kwiiparameters ezibonakalayo ezilawulekayo, inika imveliso enokuphinda ivelise kwakhona.
Ukusetyenziswa kwayo kubandakanya iziponji ze-hemostatic, ezingayeki nje ngokufanelekileyo ukopha, kodwa ziphinde zibe ne-bioabsorbable kwaye zikhawulezise inkqubo yokuphilisa ngokukhuthaza ukufuduka kweeseli zezicubu ezintsha.Okwangoku, iipatches ze-ostomy zisebenzisa i-gelatin njengento yokuncamathelisa ulusu.
Nceda uzive ukhululekile ukuqhagamshelana nathi Gelken, ingcaligelatin umenzi e-China, ukufumana iinkcukacha ezithe kratya kunye neenkcukacha.
Ixesha lokuposa: Mar-09-2023
