Ikhaya

Indlela i-gelatin yodidi lwamayeza ephucula ngayo ukuthembeka kwethebhulethi, inkangeleko, kunye nokwamkelwa kwesigulana

IGelatin ibisoloko iyinto ethembekileyo ekuvelisweni kwamayeza kangangeminyaka engaphezu kwekhulu. Ngaphaya kwamaqokobhe eekhaphukhaphu, idlala indima ebalulekileyo ekugqumeni nasekubopheni iipilisi - imisebenzi emibini echaphazela ngokuthe ngqo uzinzo lwemveliso, inkangeleko, kunye nokusebenza kwayo. Eli nqaku liphonononga indlela igelatin yodidi lwamayeza esebenza ngayo njenge-binder kunye ne-coating agent, kunye neemfuno zomgangatho kunye namaxwebhu ekufuneka ziqwalaselwe ngabaqulunqi bamayeza xa bekhetha uhlobo lwamayeza.

I-Gelatin njengesixhobo sokubopha iithebhulethi

Kwindlela yokwenza iipilisi, izihlanganisi zinceda amasuntswana ukuba enze iigranules okanye adibane kwiipilisi ezinamandla aneleyo oomatshini. IGelatin sisihlanganisi esimiselweyo kwi-granulation emanzi, apho idla ngokulungiswa njengesisombululo samanzi kwaye isasazwe ngomxube wepowder. Ukufaneleka kwayo kuxhomekeke kuxinzelelo lwegelatin, i-viscosity yesisombululo, i-API kunye nokuhambelana kwe-excipient, iimeko ze-granulation, kunye neempawu zepilisi ezifunekayo.

• Iphucula ubulukhuni bethebhulethi kwaye inciphisa ukugungqa.
• Ixhasa ukukhula kweegranule ezifanayo ngexesha lokufuma okumanzi.
• Ingasetyenziswa kumanqanaba aphantsi okubandakanya.
• Ifanelekile kwizinto ezithintela ukufuma xa isetyenziswa njengesixhobo sokubopha esomileyo.

IGelatin njengePolymer yokugquma iipilisi

Iingubo ezisekwe kwiGelatin zenza imiphezulu yeepilisi egudileyo nekhazimlayo ephucula ukuginywa, igqume incasa engathandekiyo, kwaye ikhusele umongo ekufuma kunye neoksijini. Ngokungafaniyo nezinye iipolymers zokwenziwa, igelatin isekelwe kwiproteni kwaye yamkelwe ngokubanzi kwiimarike zamayeza kunye nezondlo.

Ukwaleka okungaphantsi kunye nokutywina

I-Gelatin ibisoloko isetyenziswa njengesixhobo sokuncamathelisa kwiinkqubo zokugquma, inceda iipowders ezisetyenzisiweyo ukuba zinamathele kwithebhulethi kwaye zixhase ukwakheka komphezulu ogudileyo ngaphambi kokuba kugqitywe kamva.

Ukwambathisa ifilimu

I-Gelatin inokwenziwa ibe zizisombululo zefilimu ezinamanzi, ezidla ngokudityaniswa neeplastiki ezifana ne-glycerin okanye i-sorbitol ukuphucula ukuguquguquka. Isiphumo yithebhulethi ekhazimlayo, elula ukuyiginya enomtsalane obonakalayo.

Ukwambathisa iswekile

Kwi-sugar coating yendabuko, i-gelatin ingasetyenziswa njengenxalenye ye-glue okanye isisombululo se-sub-coating ukunceda ii-coating powders kunye nee-syrup layers zinamathele kwi-tablet core.

Iimpawu zoMgangatho weGelatin yePharma

Izinto eziqwalaselwayo malunga nokwakheka

• Nyibilikisa igelatin emanzini afudumeleyo acocekileyo kwaye uyisebenzise ngokukhawuleza ukuthintela ukukhula kweentsholongwane.
• Apho i-gelatin isetyenziswa kwinkqubo yefilimu, khetha kwaye ulungise nayiphi na i-plasticizer ngokwendlela efunekayo yokuguquguquka, ukwakheka kwe-coating, umgangatho we-gelatin, kunye neemeko zokomisa.
• Lawula ubushushu bemveliso, iimeko zokomisa, izinga lokutshiza, kunye nezinye iiparameter ezifanelekileyo zokugquma ukuze uphephe ukunamathela, iifilimu ezingalinganiyo, okanye ukomisa ngokugqithisileyo.
• Qinisekisa kwakhona ukuqhekeka, kwaye apho kufanelekileyo, ukuqhekeka emva kotshintsho olubalulekileyo kwinkqubo yokubopha okanye yokugquma.

Amanqaku Olawulo Nokufumaneka Kwemithombo

I-gelatin yamayeza kufuneka ihambelane ne-monograph ye-pharmacopoeial efanelekileyo kunye nenkcazo evunyiweyo ngumthengi kwimarike yendawo ekuyiwa kuyo. I-lot nganye enikiweyo kufuneka ixhaswe yiSatifikethi soHlalutyo esifanelekileyo, ngelixa amaxwebhu afana neengxelo zemvelaphi yezilwanyana, amaxwebhu e-TSE/BSE, ulwazi lwe-allergen, izatifikethi zeHalal okanye zeKosher, kunye nezatifikethi zenkqubo yomgangatho kufuneka zigcinwe ngokwemigaqo yazo esebenzayo kunye neemfuno zabathengi.

Izinto ezibalulekileyo ekufuneka ziqwalaselwe

I-Gelatin sisithako esisebenziseka lula nesinophawu oluhle lokubopha iipilisi kunye nokugquma. Iimpawu zayo zokwenza ifilimu kunye nokuncamathelisa zenza ukuba ifaneleke zombini ukugquma okusebenzayo kunye nokugqitywa kobuhle. Ukufaneleka kwayo kuxhomekeke kumandla ejeli, ukuxinana, uxinano, ukuhambelana kokwenziwa, iimeko zenkqubo, kunye neemfuno zomgangatho weyeza ezifanelekileyo.

Malunga nombhali

U-Eric Ma

Umlawuli jikelele

Esebenzisa amava angamashumi amabini eminyaka kwicandelo lokuvelisa i-gelatin kunye ne-collagen, u-Eric uqondise imisebenzi ecwangcisiweyo ehlala inika ukukhula okuqinileyo kweshishini kunye nokwanda kwemarike yehlabathi.